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Sex-linked dystonia parkinsonism : ウィキペディア英語版 | Sex-linked dystonia parkinsonism
Sex-linked dystonia parkinsonism, also known as Lubag Syndrome or XDP, is a rare sex-linked progressive movement disorder with high penetrance found almost exclusively in males from the Panay, Philippines. It is characterized by dystonic movements first typically occurring in the 3rd and 4th decade of life. The dystonic movements often either coexist or develop into parkinsonism within 10 years of disease onset. ==Epidemiology== Although all early reported cases occurred in the Philippines, sex-linked dystonia parkinsonism has been diagnosed in the US, Canada, and Germany in people of Filipino descent. The prevalence in the Philippines has been estimated at 1/322,000 and as high as 1/4,000 in the province of Capiz's male population. As a sex-linked recessive disease, the majority of those affected are males with females generally asymptomatic carriers.〔() Orphanet: X-linked dystonia parkinsonism. Accessed December 18th, 2014.〕 In the largest described series, the mean age of onset was 39.7 years, the mean duration of illness was 16 years, and the mean age of death was 55.6 years.
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